Fibrinogen human
Evicel, TachoSil, VeraSeal (fibrinogen, human) is an unknown pharmaceutical. Fibrinogen, human was first approved as Tachosil on 2004-06-08. It is used to treat afibrinogenemia and hemorrhage in the USA. It has been approved in Europe to treat hemostasis and surgical hemostasis.
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Indications
FDA
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Indication | Ontology | MeSH | ICD-10 |
|---|---|---|---|
| surgical hemostasis | — | D006488 | — |
| hemostasis | — | D006487 | — |
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Clinical
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844 clinical trials
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Indications Phases 4
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
|---|---|---|---|---|---|---|---|---|---|
| Hemorrhage | D006470 | MP_0001914 | R58 | 7 | 18 | 17 | 19 | 33 | 87 |
| Breast neoplasms | D001943 | EFO_0003869 | C50 | 39 | 16 | 4 | 1 | 5 | 55 |
| Carcinoma | D002277 | — | C80.0 | 18 | 23 | 16 | 1 | 2 | 53 |
| Neoplasms | D009369 | — | C80 | 39 | 13 | 3 | 1 | 2 | 51 |
| Blood coagulation disorders | D001778 | EFO_0009314 | D68.9 | 3 | 4 | 3 | 8 | 29 | 44 |
| Hemostatic disorders | D020141 | — | — | 3 | 4 | 3 | 8 | 29 | 44 |
| Wounds and injuries | D014947 | — | T14.8 | 6 | 10 | 5 | 2 | 13 | 29 |
| Afibrinogenemia | D000347 | — | D68.2 | 1 | 6 | 8 | 4 | 9 | 25 |
| Fistula | D005402 | — | — | 1 | — | 4 | 2 | 8 | 15 |
| Hernia | D006547 | HP_0100790 | K40-K46 | 1 | — | 1 | 2 | 11 | 15 |
Show 68 more
Indications Phases 3
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
|---|---|---|---|---|---|---|---|---|---|
| Recurrence | D012008 | — | — | 17 | 24 | 7 | — | 7 | 47 |
| Ovarian neoplasms | D010051 | EFO_0003893 | C56 | 9 | 11 | 7 | — | 2 | 26 |
| Adenocarcinoma | D000230 | — | — | 6 | 11 | 9 | — | — | 22 |
| Leukemia | D007938 | — | C95 | 12 | 6 | 1 | — | 4 | 19 |
| Colorectal neoplasms | D015179 | — | — | 12 | 6 | 3 | — | — | 18 |
| Fallopian tube neoplasms | D005185 | — | — | 4 | 9 | 6 | — | 1 | 18 |
| Ovarian epithelial carcinoma | D000077216 | — | — | 5 | 7 | 6 | — | 2 | 18 |
| Pterygium | D011625 | — | H11.0 | 2 | 1 | 3 | — | 10 | 15 |
| Endometrioid carcinoma | D018269 | — | — | 3 | 8 | 5 | — | — | 14 |
| Serous cystadenocarcinoma | D018284 | — | — | 3 | 8 | 5 | — | — | 14 |
Show 131 more
Indications Phases 2
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
|---|---|---|---|---|---|---|---|---|---|
| Covid-19 | D000086382 | — | — | 1 | 1 | — | — | 15 | 17 |
| Myeloid leukemia acute | D015470 | — | C92.0 | 11 | 5 | — | — | 2 | 14 |
| Myeloid leukemia | D007951 | — | C92 | 11 | 4 | — | — | 2 | 13 |
| Myelodysplastic syndromes | D009190 | — | D46 | 8 | 2 | — | — | 2 | 10 |
| Syndrome | D013577 | — | — | 6 | 2 | — | — | 4 | 10 |
| Preleukemia | D011289 | — | — | 7 | 2 | — | — | 2 | 9 |
| Multiple myeloma | D009101 | — | C90.0 | 6 | 3 | — | — | 2 | 9 |
| Plasma cell neoplasms | D054219 | — | — | 5 | 3 | — | — | 2 | 8 |
| Neoplasm metastasis | D009362 | EFO_0009708 | — | 7 | 3 | — | — | 1 | 8 |
| Infections | D007239 | EFO_0000544 | — | 3 | 2 | — | — | 3 | 7 |
Show 124 more
Indications Phases 1
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
|---|---|---|---|---|---|---|---|---|---|
| Healthy volunteers/patients | — | — | — | 4 | — | — | — | 2 | 6 |
| B-cell chronic lymphocytic leukemia | D015451 | — | C91.1 | 3 | — | — | — | 1 | 4 |
| Thrombocytopenia | D013921 | HP_0001873 | D69.6 | 1 | — | — | — | 3 | 4 |
| B-cell lymphoma | D016393 | — | — | 3 | — | — | — | 1 | 4 |
| Neutropenia | D009503 | — | D70 | 4 | — | — | — | — | 4 |
| Myeloproliferative disorders | D009196 | — | D47.1 | 2 | — | — | — | 1 | 3 |
| Aplastic anemia | D000741 | HP_0001915 | D61.9 | 3 | — | — | — | — | 3 |
| Periodontal diseases | D010510 | — | K05.6 | 1 | — | — | — | 2 | 3 |
| Chemotherapy-induced febrile neutropenia | D064146 | — | — | 3 | — | — | — | — | 3 |
| Alzheimer disease | D000544 | EFO_0000249 | F03 | 2 | — | — | — | 1 | 3 |
Show 72 more
Indications Without Phase
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
|---|---|---|---|---|---|---|---|---|---|
| Embolism | D004617 | — | — | — | — | — | — | 5 | 5 |
| Liver cirrhosis | D008103 | EFO_0001422 | K74.0 | — | — | — | — | 5 | 5 |
| Fibrosis | D005355 | — | — | — | — | — | — | 5 | 5 |
| Coagulation protein disorders | D020147 | — | — | — | — | — | — | 4 | 4 |
| Venous thromboembolism | D054556 | EFO_0004286 | I74 | — | — | — | — | 4 | 4 |
| Pulmonary embolism | D011655 | HP_0002204 | I26 | — | — | — | — | 4 | 4 |
| Venous thrombosis | D020246 | HP_0004936 | I82.40 | — | — | — | — | 3 | 3 |
| Knee osteoarthritis | D020370 | EFO_0004616 | M17 | — | — | — | — | 3 | 3 |
| Type 2 diabetes mellitus | D003924 | EFO_0001360 | E11 | — | — | — | — | 3 | 3 |
| Femoral hernia | D006550 | EFO_1001791 | K41 | — | — | — | — | 3 | 3 |
Show 166 more
Epidemiology
Epidemiological information for investigational and approved indications
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Drug
General
| Drug common name | Fibrinogen human |
| INN | — |
| Description | Evicel, TachoSil, VeraSeal (fibrinogen, human) is an unknown pharmaceutical. Fibrinogen, human was first approved as Tachosil on 2004-06-08. It is used to treat afibrinogenemia and hemorrhage in the USA. It has been approved in Europe to treat hemostasis and surgical hemostasis. |
| Classification | Unknown |
| Drug class | — |
| Image (chem structure or protein) |  |
| Structure (InChI/SMILES or Protein Sequence) | — |
Identifiers
| PDB | — |
| CAS-ID | — |
| RxCUI | — |
| ChEMBL ID | CHEMBL2109072 |
| ChEBI ID | — |
| PubChem CID | — |
| DrugBank | — |
| UNII ID | — |
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Safety
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1,704 adverse events reported
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